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Role of hepcidin in the diagnosis of sepsis and septic shock in children
- Source :
-
Turkish journal of medical sciences [Turk J Med Sci] 2018 Jun 14; Vol. 48 (3), pp. 517-524. Date of Electronic Publication: 2018 Jun 14. - Publication Year :
- 2018
-
Abstract
- Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG. Results: In distinguishing the SG and SSG from the HCG, hepcidin sensitivity and specificity were found to be 100%. Distinguishing between the PICUCG and the SG, hepcidin sensitivity was calculated as 95.6% and specificity was calculated as 100%. The sensitivity of WBC, CRP, and PCT was lower than that of hepcidin, but the sensitivity of IL-6 was higher than that of hepcidin. While the specificity of PCT and IL-6 was the same as hepcidin, the specificity of WBC and CRP was lower than that of hepcidin. Conclusion: Hepcidin is a more reliable indicator than WBC and CRP levels in distinguishing children with sepsis and septic shock from healthy children and nonseptic pediatric ICU patients.
Details
- Language :
- English
- ISSN :
- 1300-0144
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Turkish journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29914246
- Full Text :
- https://doi.org/10.3906/sag-1707-120