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Large Outbreaks of Fungal and Bacterial Bloodstream Infections in a Neonatal Unit, South Africa, 2012-2016.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2018 Jul; Vol. 24 (7), pp. 1204-1212. - Publication Year :
- 2018
-
Abstract
- Candidemia is a major cause of healthcare-associated infections. We describe a large outbreak of Candida krusei bloodstream infections among infants in Gauteng Province, South Africa, during a 4-month period; a series of candidemia and bacteremia outbreaks in the neonatal unit followed. We detected cases by using enhanced laboratory surveillance and audited hospital wards by environmental sampling and epidemiologic studies. During July-October 2014, among 589 patients, 48 unique cases of C. krusei candidemia occurred (8.2% incidence). Risk factors for candidemia on multivariable analyses were necrotizing enterocolitis, birthweight <1,500 g, receipt of parenteral nutrition, and receipt of blood transfusion. Despite initial interventions, outbreaks of bloodstream infection caused by C. krusei, rarer fungal species, and bacterial pathogens continued in the neonatal unit through July 29, 2016. Multiple factors contributed to these outbreaks; the most functional response is to fortify infection prevention and control.
- Subjects :
- Bacteremia microbiology
Bacteremia prevention & control
Child
Female
Fungemia microbiology
Fungemia prevention & control
History, 21st Century
Humans
Infant, Newborn
Male
Public Health Surveillance
Risk Factors
South Africa epidemiology
Bacteremia epidemiology
Cross Infection
Disease Outbreaks
Fungemia epidemiology
Infant, Newborn, Diseases epidemiology
Infant, Newborn, Diseases microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 24
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 29912684
- Full Text :
- https://doi.org/10.3201/eid2407.171087