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Synthetic, small-molecule photoantimicrobials - a realistic approach.
- Source :
-
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2018 Nov 01; Vol. 17 (11), pp. 1767-1779. Date of Electronic Publication: 2018 Jun 15. - Publication Year :
- 2018
-
Abstract
- The search for suitable, low-molecular weight photoantimicrobials for use in infection control has strong foundations in conventional antiseptic research from the early-mid 20 <superscript>th</superscript> Century. Many examples of dyes exist having conventional antimicrobial activity among the azine, acridine and triphenylmethane families which have since also been found to exhibit photosensitising capabilities. The prior employment of these examples in human antisepsis provides a practical basis in terms of low host toxicity, while extant structure-activity relationships for conventional antimicrobial activity can support the development of similar relationships for photoactivated cell killing. The range of chromophores covered allows progress to be made both in topical and deeper, fluid-involved infections.
- Subjects :
- Acridines chemical synthesis
Acridines chemistry
Acridines pharmacology
Anti-Infective Agents chemical synthesis
Anti-Infective Agents chemistry
Bacteria drug effects
Fungi drug effects
Hydrazines chemical synthesis
Hydrazines chemistry
Hydrazines pharmacology
Microbial Sensitivity Tests
Molecular Structure
Photosensitizing Agents chemical synthesis
Photosensitizing Agents chemistry
Small Molecule Libraries chemical synthesis
Small Molecule Libraries chemistry
Trityl Compounds chemical synthesis
Trityl Compounds chemistry
Trityl Compounds pharmacology
Viruses drug effects
Anti-Infective Agents pharmacology
Photosensitizing Agents pharmacology
Small Molecule Libraries pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1474-9092
- Volume :
- 17
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
- Publication Type :
- Academic Journal
- Accession number :
- 29905338
- Full Text :
- https://doi.org/10.1039/c8pp00145f