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Differentially regulated genes in Esr2 -mutant rat granulosa cells.
- Source :
-
Data in brief [Data Brief] 2018 May 31; Vol. 19, pp. 1008-1011. Date of Electronic Publication: 2018 May 31 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- RNA seq analyses were performed in granulosa cells (GCs) collected from gonadotropin treated ESR2 mutant rats. Data obtained from a null mutant with Esr2 exon 3 deletion (∆3) and another DNA binding domain (DBD) mutant with exon 4 deletion (∆4) were compared to that of wildtype (WT) rats. The raw data were analyzed using CLC genomics workbench. High quality RNA-sequencing reads were aligned to the Rattus norvegicus genome. Differentially expressed genes in ∆3 or ∆4 Esr2 -mutant GCs were identified based on the following criteria: FDR p-Value ≤0.05 and an absolute fold change of 2. Fewer differentially expressed genes were identified in ∆3 compared to the ∆4 mutant group. As both mutant groups demonstrated a common phenotype of ovulation failure, differentially expressed genes common to both in ∆3 and ∆4 mutant rats were emphasized and further analyzed in the companion article "ESR2 regulates granulosa cell genes essential for follicle maturation and ovulation" [1].
Details
- Language :
- English
- ISSN :
- 2352-3409
- Volume :
- 19
- Database :
- MEDLINE
- Journal :
- Data in brief
- Publication Type :
- Academic Journal
- Accession number :
- 29900397
- Full Text :
- https://doi.org/10.1016/j.dib.2018.05.098