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Network biology discovers pathogen contact points in host protein-protein interactomes.
- Source :
-
Nature communications [Nat Commun] 2018 Jun 13; Vol. 9 (1), pp. 2312. Date of Electronic Publication: 2018 Jun 13. - Publication Year :
- 2018
-
Abstract
- In all organisms, major biological processes are controlled by complex protein-protein interactions networks (interactomes), yet their structural complexity presents major analytical challenges. Here, we integrate a compendium of over 4300 phenotypes with Arabidopsis interactome (AI-1 <subscript>MAIN</subscript> ). We show that nodes with high connectivity and betweenness are enriched and depleted in conditional and essential phenotypes, respectively. Such nodes are located in the innermost layers of AI-1 <subscript>MAIN</subscript> and are preferential targets of pathogen effectors. We extend these network-centric analyses to Cell Surface Interactome (CSI <superscript>LRR</superscript> ) and predict its 35 most influential nodes. To determine their biological relevance, we show that these proteins physically interact with pathogen effectors and modulate plant immunity. Overall, our findings contrast with centrality-lethality rule, discover fast information spreading nodes, and highlight the structural properties of pathogen targets in two different interactomes. Finally, this theoretical framework could possibly be applicable to other inter-species interactomes to reveal pathogen contact points.
- Subjects :
- Arabidopsis genetics
Arabidopsis immunology
Arabidopsis Proteins immunology
Arabidopsis Proteins metabolism
Host-Pathogen Interactions
Models, Biological
Plant Diseases immunology
Plant Diseases microbiology
Plant Immunity
Protein Interaction Mapping
Protein Kinases immunology
Protein Kinases metabolism
Pseudomonas syringae pathogenicity
Systems Biology
Arabidopsis metabolism
Protein Interaction Maps
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 29899369
- Full Text :
- https://doi.org/10.1038/s41467-018-04632-8