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Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases.

Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases.

Authors :
Frommhagen M
Westphal AH
van Berkel WJH
Kabel MA
Source :
Frontiers in microbiology [Front Microbiol] 2018 May 29; Vol. 9, pp. 1080. Date of Electronic Publication: 2018 May 29 (Print Publication: 2018).
Publication Year :
2018

Abstract

Lytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively cleave glycosidic bonds in polysaccharides. The ability of these copper enzymes to boost the degradation of lignocellulose has greatly stimulated research efforts and biocatalytic applications within the biorefinery field. Initially found as oxidizing recalcitrant substrates, such as chitin and cellulose, it is now clear that LPMOs cleave a broad range of oligo- and poly-saccharides and make use of various electron-donating systems. Herein, substrate specificities and electron-donating systems of fungal LPMOs are summarized. A closer look at LPMOs as part of the fungal enzyme machinery might provide insights into their role in fungal growth and plant-pathogen interactions to further stimulate the search for novel LPMO applications.

Details

Language :
English
ISSN :
1664-302X
Volume :
9
Database :
MEDLINE
Journal :
Frontiers in microbiology
Publication Type :
Academic Journal
Accession number :
29896168
Full Text :
https://doi.org/10.3389/fmicb.2018.01080