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Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.

Authors :
Gibbs RM
Lipnick S
Bateman JW
Chen L
Cousins HC
Hubbard EG
Jowett G
LaPointe DS
McGredy MJ
Odonkor MN
Repetti G
Thomas E
Rubin LL
Source :
Cell stem cell [Cell Stem Cell] 2018 Jul 05; Vol. 23 (1), pp. 21-24. Date of Electronic Publication: 2018 Jun 07.
Publication Year :
2018

Abstract

The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1875-9777
Volume :
23
Issue :
1
Database :
MEDLINE
Journal :
Cell stem cell
Publication Type :
Academic Journal
Accession number :
29887317
Full Text :
https://doi.org/10.1016/j.stem.2018.05.019