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Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease.
- Source :
-
Frontiers in immunology [Front Immunol] 2018 May 23; Vol. 9, pp. 1119. Date of Electronic Publication: 2018 May 23 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- T-cell-mediated immune responses play a fundamental role in controlling Mycobacterium tuberculosis ( M. tuberculosis ) infection, and traditionally, this response is thought to be mediated by Th1-type CD4 <superscript>+</superscript> T-cells secreting IFN-γ. While studying the function and specificity of M. tuberculosis -reactive CD4 <superscript>+</superscript> T-cells in more detail at the single cell level; however, we found a human CD4 <superscript>+</superscript> T-cell population with a naive phenotype that interestingly was capable of producing multiple cytokines (T <subscript>CNP</subscript> cells). CD4 <superscript>+</superscript> T <subscript>CNP</subscript> cells phenotyped as CD95 <superscript>lo</superscript> CD28 <superscript>int</superscript> CD49d <superscript>hi</superscript> CXCR3 <superscript>hi</superscript> and showed a broad distribution of T cell receptor Vβ segments. They rapidly secreted multiple cytokines in response to different M. tuberculosis antigens, their frequency was increased during active disease, but was comparable to latent tuberculosis infection in treated TB patients. These results identify a novel human CD4 <superscript>+</superscript> T-cell subset involved in the human immune response to mycobacteria, which is present in active TB patients' blood. These results significantly expand our understanding of the immune response in infectious diseases.
- Subjects :
- Adult
Antigens, Bacterial immunology
CD4 Lymphocyte Count
Disease Progression
Female
Humans
Male
Phenotype
Receptors, Antigen, T-Cell, alpha-beta metabolism
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
Tuberculosis microbiology
Young Adult
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes metabolism
Cytokines metabolism
Immunophenotyping
Mycobacterium tuberculosis immunology
Tuberculosis immunology
Tuberculosis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29875774
- Full Text :
- https://doi.org/10.3389/fimmu.2018.01119