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Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA).
- Source :
-
International journal of environmental research and public health [Int J Environ Res Public Health] 2018 Jun 05; Vol. 15 (6). Date of Electronic Publication: 2018 Jun 05. - Publication Year :
- 2018
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Abstract
- We investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Urinary arsenic species, including inorganic arsenic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (Ab), were measured using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) and corrected for organic sources from seafood consumption by regressing Ab on arsenic species using a validated method. Principal components of arsenic metabolism were also used as independent phenotypes. We conducted linear regression of arsenic traits with allelic dosage of candidate single nucleotide polymorphisms (SNPs) rs12768205 (G > A), rs3740394 (A > G), and rs3740393 (G > C) measured using Illumina MetaboChip. Models were stratified by non-Hispanic white vs. all other race/ethnicity and adjusted for age, sex, arsenic exposure, study site, and population stratification. Consistent with previous studies, rs12768205 showed evidence for strongest association (non-Hispanic white: iAs% -0.14 (P 0.83), MMA% -0.66 (0.49), DMA% 0.81(0.49); other race/ethnicity: 0.13 (0.71), -1.21 (0.09), 1.08 (0.20)). No association, however, passed the strict Bonferroni p -value. This was a novel study among an ethnically diverse population exposed to low arsenic levels.
- Subjects :
- Aged
Aged, 80 and over
Arsenic urine
Atherosclerosis epidemiology
Female
Genetic Predisposition to Disease
Health Surveys
Humans
Male
Mass Spectrometry
Methyltransferases genetics
Middle Aged
Seafood toxicity
United States epidemiology
Arsenic metabolism
Atherosclerosis ethnology
Atherosclerosis genetics
Drinking Water chemistry
Ethnicity genetics
Seafood analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1660-4601
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of environmental research and public health
- Publication Type :
- Academic Journal
- Accession number :
- 29874848
- Full Text :
- https://doi.org/10.3390/ijerph15061179