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Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins in Caenorhabditis elegans .
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2018 Jun 05; Vol. 23 (6). Date of Electronic Publication: 2018 Jun 05. - Publication Year :
- 2018
-
Abstract
- Aging is a major risk factor for many prevalent diseases. Pharmacological intervention to improve the health span and extend the lifespan could be a preventive elixir for aging and age-related diseases. The non-steroid anti-inflammation medicine aspirin was reported to delay aging in Caenorhabditis elegans ( C. elegans ) and mice. We are wondering if the analogues of aspirin could also present antiaging activity. Here, we synthesized several aspirin derivatives and investigated their thermotolerance and antiaging effect in C. elegans . One of the compounds, 5-(bis(3-methylbut-2-en-1-yl)amino)-2-hydroxybenzoic acid, moderately increased the survival of C. elegans under heat stress, but could not extend the lifespan under optimum conditions. This compound could increase the mRNA level of stress response gene gst-4 , and the mRNA and protein expression level of heat shock protein hsp-16.2 under heat stress. The failure of activating the transcription factor DAF-16 might explain why this compound could not act as aspirin to extend the lifespan of C. elegans . Our results would help further the investigation of the pharmacological activity of aspirin analogues and the relationship between structures and activity.
- Subjects :
- Animals
Aspirin chemistry
Aspirin pharmacology
Caenorhabditis elegans metabolism
Caenorhabditis elegans physiology
Helminth Proteins genetics
Longevity
RNA, Messenger genetics
Adaptation, Physiological drug effects
Aspirin analogs & derivatives
Caenorhabditis elegans drug effects
Heat-Shock Response
Helminth Proteins metabolism
Hot Temperature
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 29874836
- Full Text :
- https://doi.org/10.3390/molecules23061359