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Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles.
- Source :
-
ACS combinatorial science [ACS Comb Sci] 2018 Jul 09; Vol. 20 (7), pp. 461-466. Date of Electronic Publication: 2018 Jun 18. - Publication Year :
- 2018
-
Abstract
- A 1,2,4-triazole motif is present in numerous commercialized and investigational bioactive molecules. Despite its importance for medicinal chemistry, there is a lack of convenient combinatorial approaches toward this molecular core. Herein, we present a synthetic strategy suitable for the quick preparation of a library of structurally diverse 1,2,4-triazoles in a one-pot setting. The key steps include the formation of thioureas followed by S-alkylation using 1,3-propane sultone and consecutive ring closure leading to the desired 1,2,4-triazoles. Parallel synthesis yields thousands of 1,2,4-triazoles in a cost- and time-efficient manner from commercially available chemicals.
Details
- Language :
- English
- ISSN :
- 2156-8944
- Volume :
- 20
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- ACS combinatorial science
- Publication Type :
- Academic Journal
- Accession number :
- 29874036
- Full Text :
- https://doi.org/10.1021/acscombsci.8b00060