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Drug-Loaded Plant-Virus Based Nanoparticles for Cancer Drug Delivery.

Authors :
Bruckman MA
Czapar AE
Steinmetz NF
Source :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1776, pp. 425-436.
Publication Year :
2018

Abstract

Nature has designed nanosized particles, specifically viruses, equipped to deliver cargo to cells. We report the chemical bioconjugation and shape shifting of a hollow, rod-shaped tobacco mosaic virus (TMV) to dense spherical nanoparticles (SNPs). We describe methods to transform TMV rods to spheres, load TMV rods and spheres with the chemotherapeutic drug, doxorubicin (DOX), to deliver modified particles to breast cancer cells, and to determine the IC <subscript>50</subscript> values of the plant virus-based drug delivery system.

Subjects

Subjects :
Antineoplastic Agents chemistry
Doxorubicin chemistry
Humans
Nanoparticles administration & dosage
Nanoparticles chemistry
Neoplasms genetics
Neoplasms virology
Tobacco Mosaic Virus chemistry
Tobacco Mosaic Virus genetics
Antineoplastic Agents pharmacology
Doxorubicin pharmacology
Drug Delivery Systems
Neoplasms drug therapy

Details

Language :
English
ISSN :
1940-6029
Volume :
1776
Database :
MEDLINE
Journal :
Methods in molecular biology (Clifton, N.J.)
Publication Type :
Academic Journal
Accession number :
29869258
Full Text :
https://doi.org/10.1007/978-1-4939-7808-3_28
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