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EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder.
- Source :
-
Journal of behavioral addictions [J Behav Addict] 2018 Jun 01; Vol. 7 (2), pp. 331-338. Date of Electronic Publication: 2018 Jun 05. - Publication Year :
- 2018
-
Abstract
- Background and aims This study aimed to evaluate the association between the severity of pathological gambling, serum brain-derived neurotrophic factor (BDNF) level, and the characteristics of quantitative electroencephalography (EEG) in patients with gambling disorder. Methods A total of 55 male patients aged 18-65 with gambling disorder participated. The severity of pathological gambling was assessed with the nine-item Problem Gambling Severity Index from the Canadian Problem Gambling Index (CPGI-PGSI). The Beck Depression Inventory and Lubben Social Network Scale were also assessed. Serum BDNF levels were assessed from blood samples. The resting-state EEG was recorded while the eyes were closed, and the absolute power of five frequency bands was analyzed: delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), and gamma (30-50 Hz). Results Serum BDNF level was positively correlated with theta power in the right parietal region (P4, r = .403, p = .011), beta power in the right parietal region (P4, r = .456, p = .010), and beta power in the right temporal region (T8, r = .421, p = .008). Gambling severity (CPGI-PGSI) was positively correlated with absolute beta power in the left frontal region (F7, r = .284, p = .043) and central region [(C3, r = .292, p = .038), (C4, r = .304, p = .030)]. Conclusions These findings support the hypothesis that right-dominant lateralized correlations between BDNF and beta and theta power reflect right-dominant brain activation in addiction. The positive correlations between beta power and the severity of gambling disorder may be associated with hyperexcitability and increased cravings. These findings contribute to a better understanding of brain-based electrophysiological changes and BDNF levels in patients with pathological gambling.
Details
- Language :
- English
- ISSN :
- 2063-5303
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of behavioral addictions
- Publication Type :
- Academic Journal
- Accession number :
- 29865867
- Full Text :
- https://doi.org/10.1556/2006.7.2018.43