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Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Jul; Vol. 103, pp. 1567-1576. Date of Electronic Publication: 2018 May 07. - Publication Year :
- 2018
-
Abstract
- Background: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases.<br />Objective: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model.<br />Methods: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated.<br />Results: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines.<br />Conclusion: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.<br /> (Copyright © 2018. Published by Elsevier Masson SAS.)
- Subjects :
- Animals
Bacterial Translocation drug effects
Body Weight drug effects
Chemokines metabolism
Disease Models, Animal
Feeding Behavior
Immunoglobulin A metabolism
Inflammation pathology
Intestinal Mucosa drug effects
Intestinal Mucosa pathology
Linoleic Acids, Conjugated pharmacology
Male
Mice, Inbred BALB C
Mucositis microbiology
Mucositis pathology
Tissue Distribution drug effects
Fluorouracil adverse effects
Intestines pathology
Linoleic Acids, Conjugated therapeutic use
Mucositis drug therapy
Mucositis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 103
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 29864944
- Full Text :
- https://doi.org/10.1016/j.biopha.2018.04.133