Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.

Authors :: Dai D
Sun X
Ding J
Chen Y
Hu S
Source :: Gene [Gene] 2018 Sep 25; Vol. 672, pp. 72-78. Date of Electronic Publication: 2018 Jun 01.
Publication Year :: 2018
Abstract: Farnesyl pyrophosphate synthase (FPPS) is a vital enzyme in the mevalonate pathway. Our previous study has indicated that overexpression of FPPS increases hypoxia/reoxygenation (HR) injury in Heart-derived H9c2 Cells. Hence, we designed this experiment to further investigate the effect of FPPS on myocardial ischemia/reperfusion (MIR) injury using a transgenic (Tg) model, and explore the relevant mechanisms. The results showed that when mouse hearts were subjected to ex vivo I/R, Tg mice have a higher CK and LDH, a larger myocardial infarct size and lower heart function recovery. These phenomena are associated with the increased Rac1 activity and ROS generation. These findings point to that FPPS might be a potential target in preventing MIR in vivo.<br /> (Copyright © 2018. Published by Elsevier B.V.)

Subjects :: Animals
Female
Gene Expression
Geranyltranstransferase metabolism
Male
Mice, Transgenic
Myocardial Infarction enzymology
Myocardial Infarction pathology
Myocardial Reperfusion Injury pathology
Myocardium enzymology
Myocardium pathology
Neuropeptides metabolism
Reactive Oxygen Species metabolism
rac1 GTP-Binding Protein metabolism
Geranyltranstransferase genetics
Myocardial Reperfusion Injury enzymology

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