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Post-weaning xenohormone intake affects adult rat submandibular gland in a sex-dependent manner.
- Source :
-
Oral diseases [Oral Dis] 2018 Oct; Vol. 24 (7), pp. 1235-1246. Date of Electronic Publication: 2018 Jul 09. - Publication Year :
- 2018
-
Abstract
- Objectives: We previously reported that maternal exposure to genistein and vinclozolin, ingested alone or in combination, affects submandibular salivary glands of rat offspring. Here, we investigated the responsiveness of submandibular gland when such xenohormone exposure occurs later in life.<br />Materials and Methods: Chemicals were given orally to male and female Wistar rats (1 mg/kg body weight per day), from weaning to adulthood. Submandibular glands and plasma were collected at postnatal day 100 for histologic and molecular analysis.<br />Results: Whereas no effect was observed in females, increases in granular convoluted tubules area coupled with a modification of salivary secretions were found in male submandibular glands. Genistein and vinclozolin similarly increased the mRNA expression of Cystatin C, Mucin 10, Growth factors, and plasmatic EGF. Negative correlations were found between the expressions of androgen receptor and EGF (-0.34; p < 0.05), TGFα (-0.52; p < 0.01), Mucin 10 (-0.43; p < 0.05), and Cystatin C (-0.42; p < 0.05) as well as between progesterone receptor and EGF (-0.56; p < 0.01). The Spearman correlation test revealed also a positive correlation between salivary EGF-mRNA expression and EGF in plasma (+0.32; p < 0.05).<br />Conclusion: Our findings confirm the sex-dependent sensitivity of submandibular salivary glands to dietary xenohormones and underline the influence of the exposure period.<br /> (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
- Subjects :
- Animals
Cystatin C genetics
Epidermal Growth Factor blood
Epidermal Growth Factor genetics
Female
Male
Rats
Receptors, Androgen genetics
Sex Factors
Submandibular Gland metabolism
Submandibular Gland pathology
Transforming Growth Factor alpha genetics
Weaning
Androgen Antagonists pharmacology
Genistein pharmacology
Oxazoles pharmacology
Phytoestrogens pharmacology
RNA, Messenger metabolism
Submandibular Gland drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1601-0825
- Volume :
- 24
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Oral diseases
- Publication Type :
- Academic Journal
- Accession number :
- 29863768
- Full Text :
- https://doi.org/10.1111/odi.12907