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Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.
- Source :
-
The European journal of neuroscience [Eur J Neurosci] 2018 Jun; Vol. 47 (12), pp. 1534-1562. Date of Electronic Publication: 2018 Jun 19. - Publication Year :
- 2018
-
Abstract
- Aberrant epileptic activity is detectable at early disease stages in Alzheimer's disease (AD) patients and in AD mouse models. Here, we investigated in young ArcticAβ mice whether AD-like pathology renders neuronal networks more susceptible to the development of acquired epilepsy induced by unilateral intrahippocampal injection of kainic acid (IHK). In this temporal lobe epilepsy model, IHK induces a status epilepticus followed after two weeks by spontaneous recurrent seizures (SRS). ArcticAβ mice exhibited more severe status epilepticus and early onset of SRS. This hyperexcitable phenotype was characterized in CA1 neurons by decreased synaptic strength, increased kainic acid-induced LTP and reduced frequency of spontaneous inhibitory currents. However, no difference in neurodegeneration, neuroinflammation, axonal reorganization or adult neurogenesis was observed in ArcticAβ mice compared to wild-type littermates following IHK-induced epileptogenesis. Neuropeptide Y (NPY) expression was reduced at baseline and its IHK-induced elevation in mossy fibres and granule cells was attenuated. However, although this alteration might underlie premature seizure onset, neutralization of soluble Aβ species by intracerebroventricular Aβ-specific antibody application mitigated the hyperexcitable phenotype of ArcticAβ mice and prevented early SRS onset. Therefore, the development of seizures at early stages of AD is mediated primarily by Aβ species causing widespread changes in synaptic function.<br /> (© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
- Subjects :
- Animals
CA1 Region, Hippocampal metabolism
CA1 Region, Hippocampal physiopathology
Dentate Gyrus metabolism
Dentate Gyrus physiopathology
Disease Models, Animal
Electroencephalography
Excitatory Amino Acid Agonists pharmacology
Kainic Acid pharmacology
Male
Mice
Mice, Transgenic
Status Epilepticus metabolism
Status Epilepticus physiopathology
Alzheimer Disease metabolism
Alzheimer Disease physiopathology
Amyloid beta-Peptides metabolism
Epilepsy, Temporal Lobe metabolism
Epilepsy, Temporal Lobe physiopathology
Hippocampus metabolism
Hippocampus physiopathology
Neuronal Plasticity physiology
Seizures metabolism
Seizures physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-9568
- Volume :
- 47
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The European journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 29862588
- Full Text :
- https://doi.org/10.1111/ejn.13983