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Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery.
- Source :
-
Disease markers [Dis Markers] 2018 May 16; Vol. 2018, pp. 5064684. Date of Electronic Publication: 2018 May 16 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Background: The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored.<br />Materials and Methods: Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded.<br />Results: Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels.<br />Conclusions: MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction.
- Subjects :
- Aged
Biomarkers blood
Biomarkers urine
Case-Control Studies
Female
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Respiration, Artificial
Sepsis blood
Sepsis etiology
Sepsis urine
Severity of Illness Index
Survival Analysis
Abdomen surgery
Matrix Metalloproteinase 9 blood
Matrix Metalloproteinase 9 urine
Sepsis metabolism
Tissue Inhibitor of Metalloproteinase-1 blood
Tissue Inhibitor of Metalloproteinase-1 urine
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8630
- Volume :
- 2018
- Database :
- MEDLINE
- Journal :
- Disease markers
- Publication Type :
- Academic Journal
- Accession number :
- 29861795
- Full Text :
- https://doi.org/10.1155/2018/5064684