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Drug-induced hyperglycaemia and diabetes: pharmacogenomics perspectives.

Authors :
Liu MZ
He HY
Luo JQ
He FZ
Chen ZR
Liu YP
Xiang DX
Zhou HH
Zhang W
Source :
Archives of pharmacal research [Arch Pharm Res] 2018 Jul; Vol. 41 (7), pp. 725-736. Date of Electronic Publication: 2018 Jun 01.
Publication Year :
2018

Abstract

Drug-induced diabetes is widely reported in clinical conditions, and it is becoming a global issue because of its potential to increase the risk of severe cardiovascular complications. However, which drug mechanisms exert their diabetogenic effects and why the effects present significant inter-individual differences remain largely unknown. Pharmacogenomics, which is the study of how genomic variation influences drug responses, provides an explanation for individual differences in drug-induced diabetes. We highlight that pharmacogenomics can be involved in regulating the expression of genes in signaling pathways related to the pharmacokinetics or pharmacodynamics of drugs or the pathogenesis of diabetes, contributing to the differences in drug-induced glucose impairment. The pharmacogenomics studies of the major diabetogenic drugs are reviewed, including calcineurin inhibitors, antipsychotics, hormones, and antihypertensive drugs. We intend to elucidate the genetic basis of drug-induced diabetes and pave the way for the precise use of these drugs in the clinic.

Details

Language :
English
ISSN :
1976-3786
Volume :
41
Issue :
7
Database :
MEDLINE
Journal :
Archives of pharmacal research
Publication Type :
Academic Journal
Accession number :
29858981
Full Text :
https://doi.org/10.1007/s12272-018-1039-x