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Radioprotection of EMT6 tumor by a new class of radioprotectors based on a pseudo-peptide cysteamine combination.

Authors :
Lespinasse F
Oiry J
Fatome M
Ardouin P
Imbach J
Malaise EP
Guichard M
Source :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 1985 May; Vol. 11 (5), pp. 1035-8.
Publication Year :
1985

Abstract

Although WR-2721 preferentially protects normal tissues against irradiation, it seemed desirable to find other drugs presenting a lower toxicity and the same radioprotective properties. A new compound, I 102, was selected; it was characterized on one hand by a coupling between cysteamine and an amino-acid, and on the other hand by an acetyl-group, which protects the thiol function. The effects of WR-2721 and of I 102 were studied on EMT6 tumors grafted on BALB/c mice. Whatever the size of the tumor, the cell survival increased as a function of the time elapsed between the injection of I 102 and the end of the irradiation (TI). In contrast, the radioprotection afforded by WR-2721 was found to be independent of TI. The survival curves suggest that, like WR-2721, I 102 protects essentially oxygenated cells.

Details

Language :
English
ISSN :
0360-3016
Volume :
11
Issue :
5
Database :
MEDLINE
Journal :
International journal of radiation oncology, biology, physics
Publication Type :
Academic Journal
Accession number :
2985525
Full Text :
https://doi.org/10.1016/0360-3016(85)90128-2