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Radioprotection of EMT6 tumor by a new class of radioprotectors based on a pseudo-peptide cysteamine combination.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 1985 May; Vol. 11 (5), pp. 1035-8. - Publication Year :
- 1985
-
Abstract
- Although WR-2721 preferentially protects normal tissues against irradiation, it seemed desirable to find other drugs presenting a lower toxicity and the same radioprotective properties. A new compound, I 102, was selected; it was characterized on one hand by a coupling between cysteamine and an amino-acid, and on the other hand by an acetyl-group, which protects the thiol function. The effects of WR-2721 and of I 102 were studied on EMT6 tumors grafted on BALB/c mice. Whatever the size of the tumor, the cell survival increased as a function of the time elapsed between the injection of I 102 and the end of the irradiation (TI). In contrast, the radioprotection afforded by WR-2721 was found to be independent of TI. The survival curves suggest that, like WR-2721, I 102 protects essentially oxygenated cells.
- Subjects :
- Amifostine pharmacology
Animals
Bone Marrow drug effects
Bone Marrow radiation effects
Cell Line
Cell Survival drug effects
Cell Survival radiation effects
Cysteamine pharmacology
Gamma Rays
Hematopoiesis drug effects
Hematopoiesis radiation effects
Lethal Dose 50
Mammary Neoplasms, Experimental pathology
Mice
Mice, Inbred BALB C
Time Factors
Whole-Body Irradiation
Cysteamine analogs & derivatives
Mammary Neoplasms, Experimental radiotherapy
Radiation-Protective Agents
Subjects
Details
- Language :
- English
- ISSN :
- 0360-3016
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 2985525
- Full Text :
- https://doi.org/10.1016/0360-3016(85)90128-2