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Intrauterine exposure to metformin: Evaluation of endothelial and perivascular adipose tissue function in abdominal aorta of adult offspring.
- Source :
-
Life sciences [Life Sci] 2018 Aug 15; Vol. 207, pp. 72-79. Date of Electronic Publication: 2018 May 29. - Publication Year :
- 2018
-
Abstract
- The biguanide metformin (MET) has been used during pregnancy for treatment of polycystic ovary syndrome and gestational diabetes. MET crosses the placenta and maternal treatment can expose the progeny to this drug during important phases of body development. Direct vascular protective effects have been described with the treatment of metformin. Nevertheless, it is unclear whether intrauterine exposure to metformin is safe for the vascular system of offspring. Thus, the present study aimed to investigate the intrinsic effects of metformin exposure in utero in the offspring abdominal aorta reactivity, in the presence and absence of perivascular adipose tissue (PVAT) and endothelium. For this, Wistar rats were treated with metformin 293 mg/kg/day (MET) or water (CTR) by gavage during the gestational period. The abdominal aorta reactivity to phenylephrine, acetylcholine, and sodium nitroprusside was evaluated in male adult offspring. It was observed that abdominal aorta relaxation was similar between MET and CTR groups in the presence or absence of PVAT. In addition, the contraction to phenylephrine was similar between MET and CTR groups in the presence and absence of PVAT and endothelium. Therefore, metformin exposure during pregnancy had no intrinsic effect on the offspring abdominal aorta PVAT and endothelial function, demonstrating it to be safe to the vascular system of the offspring.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adipose Tissue drug effects
Adipose Tissue physiology
Animals
Aorta, Abdominal drug effects
Body Weight drug effects
Dose-Response Relationship, Drug
Endothelial Cells drug effects
Endothelial Cells physiology
Endothelium, Vascular drug effects
Endothelium, Vascular physiology
Female
Male
Nitroprusside pharmacology
Pregnancy
Pregnancy, Animal
Prenatal Exposure Delayed Effects
Rats
Rats, Wistar
Vasoconstriction drug effects
Vasodilation drug effects
Aorta, Abdominal physiology
Maternal Exposure
Metformin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 207
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29852188
- Full Text :
- https://doi.org/10.1016/j.lfs.2018.05.050