Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance.

Objective: To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPAR γ ) with glucolipid metabolism in Chinese Han population.
Methods: Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group ( n = 198) and abnormal glucose tolerance group ( n = 358). HbA1c, blood lipid profile, plasma glucose, and insulin were determined. Insulin sensitivity (HOMA-IR and Matsuda index (ISI _M )) and insulin secretion indexes (HOMA- β , early and total phase disposition index) were evaluated. Eight potential functional SNPs in UCP2 and 7 in PPAR γ were selected. SNPs were genotyped on Sequenom MassARRAY platform.
Results: The GG genotype of rs2920502 in PPAR γ was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95%CI: 0.526-0.969, P = 0.042; GG: OR: 0.715, 95%CI: 0.527-0.97, P = 0.031). The TT genotype of rs3856806 in PPAR γ was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95%CI: 1.055-2.017, P = 0.022; TT: OR: 1.58, 95%CI: 1.104-2.761, P = 0.032). The GG genotype of rs2920502 in PPAR γ had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes.
Conclusion: It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2. The GG genotype of rs2920502 in PPAR γ had a decreased risk for diabetes. The TT genotype of rs3856806 in PPAR γ had an increased risk for diabetes.