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[Genetic and Environmental Factors in Childhood Affecting High Brain Function].
- Source :
-
Nihon eiseigaku zasshi. Japanese journal of hygiene [Nihon Eiseigaku Zasshi] 2018; Vol. 73 (2), pp. 110-114. - Publication Year :
- 2018
-
Abstract
- The brain and mind are not only determined genetically but are also nurtured by environmental stimuli in early life. However, the relationship between early life environment and phenotypes in adulthood remains elusive. Using the IntelliCage-based competition task for group-housed mice, we previously found that maternal exposure to a low dose of an environmental pollutant, dioxin, resulted in abnormal social behavior, that is, low competitive dominance, which is defined by decreased occupancy of limited resource sites under highly competitive circumstances. Although we were unable to identify which behavioral phenotype applies to abnormalities such as "human social nature", we found signs of hypoactivation of the medial prefrontal cortex, as seen in patients with autism spectrum disorder. In addition, another model of environmental factors, repeated isolation during development, and that of genetic factors including mice with neuronal heterotopia, which refers to brain malformations resulting from deficits of neuronal migration, showed low competitive dominance. These results indicate that a constitutive approach to capture the neural network of the whole brain is necessary especially in cases where the temporal gap of causal relationships is large such as DOHaD.
- Subjects :
- Animals
Autism Spectrum Disorder genetics
Autism Spectrum Disorder physiopathology
Behavior, Animal
Brain physiopathology
Child
Child, Preschool
Competitive Behavior
Dioxins adverse effects
Environmental Pollutants adverse effects
Female
Humans
Mice
Models, Animal
Nerve Net physiology
Brain growth & development
Brain physiology
Maternal Exposure adverse effects
Social Behavior
Social Environment
Subjects
Details
- Language :
- Japanese
- ISSN :
- 1882-6482
- Volume :
- 73
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nihon eiseigaku zasshi. Japanese journal of hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 29848860
- Full Text :
- https://doi.org/10.1265/jjh.73.110