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Prevalence of Enhancer of Zeste Homolog 2 in Patients with Resected Small Cell Lung Cancer.
- Source :
-
Anticancer research [Anticancer Res] 2018 Jun; Vol. 38 (6), pp. 3707-3711. - Publication Year :
- 2018
-
Abstract
- Background/aim: Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is deeply involved in cancer pathogenesis. Although clinicopathological significance of EZH2 in non-small cell lung cancer has been gradually elucidated, such significance in small cell lung cancer (SCLC) has yet to be fully investigated.<br />Patients and Methods: Forty patients with resected SCLC were analyzed for EZH2. EZH2 expression was evaluated using the Allred score (0-8) and was classified into negative (0-6) and positive (7 and 8). We evaluated the association between EZH2 and the clinicopathological characteristics and postoperative survivals.<br />Results: Among 40 patients, 15 (37.5%) and 25 (62.5%) were classified as being negative and positive for EZH2, respectively. Fisher's exact test demonstrated no significant associations between the positivity for EZH2 and clinicopathological characteristics. No significant differences were observed in recurrence-free and overall survivals between EZH2-negative/low and EZH2-high patients.<br />Conclusion: EZH2 was frequently observed in patients with resected SCLC, but no significant associations were found between its expression and the clinicopathological characteristics and postoperative survivals.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Disease-Free Survival
Female
Humans
Immunohistochemistry
Lung pathology
Lung surgery
Lung Neoplasms surgery
Male
Outcome Assessment, Health Care methods
Outcome Assessment, Health Care statistics & numerical data
Prognosis
Small Cell Lung Carcinoma surgery
Enhancer of Zeste Homolog 2 Protein biosynthesis
Lung metabolism
Lung Neoplasms metabolism
Small Cell Lung Carcinoma metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 38
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 29848731
- Full Text :
- https://doi.org/10.21873/anticanres.12649