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Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa.

Authors :
Snesrud E
Maybank R
Kwak YI
Jones AR
Hinkle MK
McGann P
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Jul 27; Vol. 62 (8). Date of Electronic Publication: 2018 Jul 27 (Print Publication: 2018).
Publication Year :
2018

Abstract

Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical isolates identified a chromosomal copy of mcr-5 within a Tn 3 -like transposon in P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of mcr in colistin-nonsusceptible P. aeruginosa .

Subjects

Subjects :
Drug Resistance, Bacterial genetics
Escherichia coli drug effects
Escherichia coli genetics
Escherichia coli Proteins genetics
Escherichia coli Proteins metabolism
Microbial Sensitivity Tests
Pseudomonas aeruginosa genetics
Anti-Bacterial Agents pharmacology
Colistin pharmacology
Pseudomonas aeruginosa drug effects

Details

Language :
English
ISSN :
1098-6596
Volume :
62
Issue :
8
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
29844041
Full Text :
https://doi.org/10.1128/AAC.00679-18
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