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Selective abdominal venous congestion to investigate cardiorenal interactions in a rat model.
- Source :
-
PloS one [PLoS One] 2018 May 29; Vol. 13 (5), pp. e0197687. Date of Electronic Publication: 2018 May 29 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Abdominal congestion may play an important role in the cardiorenal syndrome and has been demonstrated to drive disease progression. An animal model for abdominal congestion, without other culprit mechanisms that are often present in patients such as low cardiac output or chronic kidney disease, might be interesting to allow a better study of the pathophysiology of the cardiorenal syndrome. The objective of this study was to develop a clinically relevant and valid rat model with abdominal venous congestion and without pre-existing heart and/or kidney dysfunction. To do so, a permanent surgical constriction (20 Gauge) of the thoracic inferior vena cava (IVC) was applied in male Sprague Dawley rats (IVCc, n = 7), which were compared to sham-operated rats (SHAM, n = 6). Twelve weeks after surgery, abdominal venous pressure (mean: 13.8 vs 4.9 mmHg, p < 0.01), plasma creatinine (p < 0.05), plasma cystatin c (p < 0.01), urinary albumin (p < 0.05), glomerular surface area (p < 0.01) and width of Bowman's space (p < 0.05) of the IVCc group were significantly increased compared to the SHAM group for a comparable absolute body weight between groups (559 vs 530g, respectively, p = 0.73). Conventional cardiac echocardiographic and hemodynamic parameters did not differ significantly between both groups, indicating that cardiac function was not compromised by the surgery. In conclusion, we demonstrate that constriction of the thoracic IVC in adult rats is feasible and significantly increases the abdominal venous pressure to a clinically relevant level, thereby inducing abdominal venous congestion.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Albumins metabolism
Animals
Cardio-Renal Syndrome etiology
Cardio-Renal Syndrome physiopathology
Creatinine blood
Cystatins blood
Disease Models, Animal
Disease Progression
Echocardiography
Hyperemia complications
Male
Rats
Rats, Sprague-Dawley
Vena Cava, Inferior surgery
Venous Pressure
Cardio-Renal Syndrome diagnostic imaging
Hyperemia etiology
Hyperemia physiopathology
Vena Cava, Inferior physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 29813081
- Full Text :
- https://doi.org/10.1371/journal.pone.0197687