Back to Search
Start Over
Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.
- Source :
-
Trends in genetics : TIG [Trends Genet] 2018 Aug; Vol. 34 (8), pp. 574-577. Date of Electronic Publication: 2018 May 26. - Publication Year :
- 2018
-
Abstract
- Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.<br /> (Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Animals
DNA Helicases chemistry
DNA Helicases genetics
DNA-Binding Proteins chemistry
DNA-Binding Proteins genetics
Disease Susceptibility
Gene Expression Regulation
Humans
Signal Transduction
Transcription Factors chemistry
Transcription Factors genetics
Ubiquitin-Protein Ligases genetics
DNA Helicases metabolism
DNA-Binding Proteins metabolism
Transcription Factors metabolism
Ubiquitin-Protein Ligases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0168-9525
- Volume :
- 34
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in genetics : TIG
- Publication Type :
- Academic Journal
- Accession number :
- 29807746
- Full Text :
- https://doi.org/10.1016/j.tig.2018.04.006