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Immune aberrations in children with Autism Spectrum Disorder: a case-control study from a tertiary care neuropsychiatric hospital in India.
- Source :
-
Psychoneuroendocrinology [Psychoneuroendocrinology] 2018 Aug; Vol. 94, pp. 162-167. Date of Electronic Publication: 2018 May 04. - Publication Year :
- 2018
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Abstract
- Multiple studies have identified the presence of peripheral immune aberrations in subjects with Autism Spectrum Disorder (ASD). However, comprehensive assessment of these peripheral immune aberrations, in the cellular and systemic compartments, in a single group of subjects with ASD is lacking. We assessed proportions of various subsets of immune cells in peripheral blood (T helper cells, T regulatory cells, B cells, monocytes, Natural Killer cells, dendritic cells) by multi-parametric flow cytometry in 50 children with ASD and compared it with thirty healthy controls matched for age, gender, socio-economic status and body mass index. There were no significant differences noted in the proportion of T regulatory cells, B cells, monocytes and Natural Killer cells, between ASD subjects and controls. On the contrary, the proportion of activated Th17 and myeloid dendritic cells were significantly higher in children with ASD. Based on these findings, group comparison of serum levels of Th17 cytokines (interleukin-6, interleukin-17A) was performed. Elevated serum levels of interleukin-6 and interleukin-17A in children with ASD corroborated our immunophenotyping findings. We did not find any significant differences among the pro-inflammatory (interleukin-1β), Th1 (interferon-γ) and Th2 (interleukin-4) cytokines. This is the first evidence with concurrent findings from immunophenotyping and cytokine data demonstrating activation of the Th17 pathway in subjects with ASD. This finding assumes significance in the light of recent maternal immune activation mouse model study that has highlighted the role of Th17 pathway in the pathophysiology of ASD. Future longitudinal studies are needed to clarify the role of this dysregulated immune pathway in the development of ASD.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Cytokines blood
Dendrites immunology
Female
Flow Cytometry
Humans
Immunophenotyping methods
India
Inflammation metabolism
Interleukin-17 analysis
Interleukin-17 blood
Interleukin-6 analysis
Interleukin-6 blood
Male
Monocytes immunology
Myeloid Cells metabolism
Prospective Studies
Tertiary Healthcare
Th17 Cells immunology
Th17 Cells metabolism
Autism Spectrum Disorder immunology
Th17 Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3360
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- Psychoneuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 29804052
- Full Text :
- https://doi.org/10.1016/j.psyneuen.2018.05.002