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Ultra-small nanocluster mediated synthesis of Nd 3+ -doped core-shell nanocrystals with emission in the second near-infrared window for multimodal imaging of tumor vasculature.
- Source :
-
Biomaterials [Biomaterials] 2018 Aug; Vol. 175, pp. 30-43. Date of Electronic Publication: 2018 May 15. - Publication Year :
- 2018
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Abstract
- In-vivo intravital short wavelength infrared (SWIR, 1000-2300 nm) fluorescence imaging has attracted considerable attention in the imaging of tumor vasculature due to its low background, high sensitivity, and deep penetration. It can noninvasively provide dynamic feedback on the tumorigenesis, growth, necrosis and metastasis. Herein, monodisperse Nd <superscript>3+</superscript> -doped core-shell downconversion luminescent nanocrystals with strong emission in the second near-infrared (NIR II) window, strong temperature-dependent paramagnetism and fast attenuation to X-rays were prepared from ultra-small nanoclusters. The use of nanoclusters resulted in very uniform bright nanocrystals with a relative quantum yield comparable to the standard dye IR-26. These bright NIR nanocrystals were modified with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] to endow with excellent water-solubility, biocompatibility and a blood circulation half-life of 5.9 h. They were then successfully used to demonstrate the variation of tumor vasculature with tumor progression from tumorigenesis, growth, to necrosis in the subcutaneous breast tumor through the NIR II fluorescence imaging. They were also used as contrast agent of magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging of tumor to provide complementary anatomic structure. Their great potential in NIR II imaging of tumor was further demonstrated with an orthotopic breast tumor. Their in-vivo biosafety was also investigated by hemanalysis and histological analyses.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Breast Neoplasms blood supply
Cell Line, Tumor
Cell Survival
Female
Heterografts
Humans
Infrared Rays
Magnetic Resonance Imaging
Mice, Inbred BALB C
Multimodal Imaging
Optical Imaging
Phosphatidylethanolamines chemistry
Polyethylene Glycols chemistry
Solubility
Tomography, X-Ray Computed
Breast Neoplasms diagnostic imaging
Contrast Media chemistry
Fluorescent Dyes chemistry
Nanoparticles chemistry
Neodymium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5905
- Volume :
- 175
- Database :
- MEDLINE
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 29800756
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2018.05.021