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Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.
- Source :
-
International journal of epidemiology [Int J Epidemiol] 2018 Aug 01; Vol. 47 (4), pp. 1207-1216. - Publication Year :
- 2018
-
Abstract
- Background: It is often assumed that selection (including participation and dropout) does not represent an important source of bias in genetic studies. However, there is little evidence to date on the effect of genetic factors on participation.<br />Methods: Using data on mothers (N = 7486) and children (N = 7508) from the Avon Longitudinal Study of Parents and Children, we: (i) examined the association of polygenic risk scores for a range of sociodemographic and lifestyle characteristics and health conditions related to continued participation; (ii) investigated whether associations of polygenic scores with body mass index (BMI; derived from self-reported weight and height) and self-reported smoking differed in the largest sample with genetic data and a subsample who participated in a recent follow-up; and (iii) determined the proportion of variation in participation explained by common genetic variants, using genome-wide data.<br />Results: We found evidence that polygenic scores for higher education, agreeableness and openness were associated with higher participation; and polygenic scores for smoking initiation, higher BMI, neuroticism, schizophrenia, attention-deficit hyperactivity disorder (ADHD) and depression were associated with lower participation. Associations between the polygenic score for education and self-reported smoking differed between the largest sample with genetic data [odds ratio (OR) for ever smoking per standard deviation (SD) increase in polygenic score: 0.85, 95% confidence interval (CI): 0.81, 0.89} and subsample (OR: 0.96, 95% CI: 0.89, 1.03). In genome-wide analysis, single nucleotide polymorphism based heritability explained 18-32% of variability in participation.<br />Conclusions: Genetic association studies, including Mendelian randomization, can be biased by selection, including loss to follow-up. Genetic risk for dropout should be considered in all analyses of studies with selective participation.
- Subjects :
- Adolescent
Child
Child, Preschool
Female
Genome-Wide Association Study
Humans
Infant
Infant, Newborn
Longitudinal Studies
Male
Risk Factors
Selection Bias
United Kingdom
Young Adult
Body Mass Index
Genetic Predisposition to Disease
Genetic Variation
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3685
- Volume :
- 47
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 29800128
- Full Text :
- https://doi.org/10.1093/ije/dyy060