Back to Search
Start Over
Cutaneous toxicities of new treatments for melanoma.
- Source :
-
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2018 Nov; Vol. 20 (11), pp. 1373-1384. Date of Electronic Publication: 2018 May 24. - Publication Year :
- 2018
-
Abstract
- New drugs against advanced melanoma have emerged during last decade. Target therapy and immunotherapy have changed the management of patients with metastatic disease. Along with its generalized use, drug toxicities have appeared and the skin is the target organ of a significant part of them. This revision summarizes the most common side effects and consensus management to improve the compliance of therapies and patients' quality of life. Among the BRAF inhibitors, main cutaneous side effects are photosensitivity, plantar hyperkeratosis, and the appearance of verrucal keratosis or squamous cell carcinoma. Special attention must be paid to the development of new primary melanomas or changes on nevi during BRAF inhibitor therapy. The most common cutaneous side effects of immunotherapy are rash, pruritus, and vitiligo. It remains controversial the possible role of these toxicities as markers of response to therapy.
- Subjects :
- Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized adverse effects
Drug Eruptions pathology
Humans
Melanoma pathology
Molecular Targeted Therapy methods
Nivolumab administration & dosage
Nivolumab adverse effects
Protein Kinase Inhibitors therapeutic use
Proto-Oncogene Proteins B-raf genetics
Proto-Oncogene Proteins B-raf immunology
Skin Neoplasms pathology
Drug Eruptions etiology
Drugs, Investigational adverse effects
Immunotherapy adverse effects
Melanoma therapy
Molecular Targeted Therapy adverse effects
Skin Neoplasms therapy
Therapies, Investigational adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1699-3055
- Volume :
- 20
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
- Publication Type :
- Academic Journal
- Accession number :
- 29799097
- Full Text :
- https://doi.org/10.1007/s12094-018-1891-7