[Research progress of microRNA and its non-viral vector in intervertebral disc degeneration].

Authors :: Huang Y
Feng G
Liu L
Li T
Liu H
Song Y
Source :: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2017 Jan 01; Vol. 31 (1), pp. 116-121.
Publication Year :: 2017
Abstract: Objective: To summarize the research progress of microRNA (miRNA) and its non-viral vector in intervertebral disc degeneration (IDD) and to investigate the potential of non-viral vector delivery of miRNA in clinical application.<br />Methods: The related literature about the role of miRNA in IDD and its non-viral delivery system was reviewed and analyzed.<br />Results: MiRNA can regulate the related gene expression level and further participate in the pathophysiologic process in degenerated intervertebral disc, miRNA delivered by various non-viral vectors has obtained an ideal effect in some diseases.<br />Conclusion: MiRNA plays a great role in the cellular and molecular mechanisms of IDD, as a safe and effective strategy for gene therapy, non-viral vector provides new possibilities for IDD treated with miRNA.

Subjects :: Gene Expression
Gene Expression Profiling
Intervertebral Disc
Genetic Therapy
Intervertebral Disc Degeneration therapy
MicroRNAs therapeutic use

Language :: Chinese
ISSN :: 1002-1892
Volume :: 31
Issue :: 1
Database :: MEDLINE
Journal :: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Publication Type :: Academic Journal
Accession number :: 29798640
Full Text :: https://doi.org/10.7507/1002-1892.201609092

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