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Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2018 Nov; Vol. 233 (11), pp. 8908-8918. Date of Electronic Publication: 2018 May 24. - Publication Year :
- 2018
-
Abstract
- Umbelliprenin (UMB) has shown various pharmacological properties in vitro. We investigated the antineoplastic and immunostimulatory effects of UMB in 4T1 mammary-tumor-bearing mice. Two-hundred microliter of UMB (12.5 mg/ml) was intraperitoneally administrated to healthy and tumor-bearing female Balb/c mice for a period of 18 days. Data was analyzed using GraphPad Prism 5 software for Windows (version 5, La Jolla, CA). UMB caused a significant decrease in tumor size (P < 0.01). Serum interferon gamma (IFNγ) was augmented in both healthy and tumor-bearing animals (P < 0.01), and IL-4 declined in healthy animals (P < 0.01) treated with UMB. Expressions of Ki-67, VEGF, CD31, MMP2, MMP9, VCAM1, and NF-κB were significantly decreased in tumors from UMB-treated animals (P < 0.001), whereas E-Cadherin and TNFR1 expressions were markedly increased (P < 0.001). The rates of liver and lung metastases in UMB-administrated animals were smaller compared to the control. UMB can potently inhibit tumor growth, angiogenesis, metastasis, and inflammation and potentiate an antitumor immune response in vivo. However, further investigations are required to evaluate the UMB mechanisms of action in cancerous cells.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Cell Line, Tumor
Cell Proliferation drug effects
Female
Humans
Inflammation blood
Inflammation genetics
Inflammation pathology
Interferon-gamma blood
Mammary Neoplasms, Animal blood
Mammary Neoplasms, Animal genetics
Mammary Neoplasms, Animal pathology
Mice
Mice, Inbred BALB C
Neoplasm Metastasis
Neoplasm Proteins genetics
Neovascularization, Pathologic blood
Neovascularization, Pathologic genetics
Neovascularization, Pathologic pathology
Inflammation drug therapy
Mammary Neoplasms, Animal drug therapy
Neovascularization, Pathologic drug therapy
Umbelliferones administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4652
- Volume :
- 233
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 29797576
- Full Text :
- https://doi.org/10.1002/jcp.26814