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Radiation exposure after 177 Lu-DOTATATE and 177 Lu-PSMA-617 therapy.
- Source :
-
Annals of nuclear medicine [Ann Nucl Med] 2018 Aug; Vol. 32 (7), pp. 499-502. Date of Electronic Publication: 2018 May 23. - Publication Year :
- 2018
-
Abstract
- Purpose: As radionuclide therapy is gaining importance in palliative treatment of patients suffering from neuroendocrine tumour (NET) as well as castration resistant prostate cancer (CRPC), the radiation protection of patients, staff, family members and the general public is of increasing interest. Here, we determine patient discharge dates according to European guidelines.<br />Methods: In 40 patients with NET and 25 patients with CRPC organ and tumour doses based on the MIRD concept were calculated from data obtained during the first therapy cycle. Planar whole body images were recorded at 0.5, 4, 20, 68 und 92 h postinjection. Residence times were calculated from the respective time-activity-curves based on the conjugated view method. Residence times for critical organs were fitted into the commercially available OLINDA software to calculate the organ doses. The doses of tumours and salivary glands were calculated via their self-irradiation by approximation with spheres of equivalent volume. Kidney volumes were gained by organ segmentation, volumes of all other organs were estimated by means of OLINDA and hence were lean body mass corrected. Out of the whole body curves reference points for patient discharge were estimated.<br />Results: In patients with NET discharge dates could be properly estimated from dosimetric data, which is not only crucial for radiation protection, but also makes therapy planning easier. For <superscript>177</superscript> Lu-PSMA-617 ligand therapy it is difficult to seriously estimate a generalized discharge date due to large interpatient variation resulting from different tumor loads and heavy pre-treatment.<br />Conclusion: Patient release is predictable for <superscript>177</superscript> Lu-DOTATATE therapy but not for <superscript>177</superscript> Lu-PSMA ligand therapy.
- Subjects :
- Humans
Kidney diagnostic imaging
Kidney radiation effects
Lutetium
Neoplasms diagnostic imaging
Octreotide therapeutic use
Organs at Risk
Prostate-Specific Antigen
Radiometry
Salivary Glands diagnostic imaging
Salivary Glands radiation effects
Single Photon Emission Computed Tomography Computed Tomography
Whole Body Imaging
Dipeptides therapeutic use
Heterocyclic Compounds, 1-Ring therapeutic use
Neoplasms radiotherapy
Octreotide analogs & derivatives
Organometallic Compounds therapeutic use
Radiotherapy Dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1864-6433
- Volume :
- 32
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Annals of nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29797003
- Full Text :
- https://doi.org/10.1007/s12149-018-1264-x