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Association of Colistin-Resistant KPC Clonal Strains with Subsequent Infections and Colonization and Biofilm Production.
- Source :
-
Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2018 Dec; Vol. 24 (10), pp. 1441-1449. Date of Electronic Publication: 2018 May 24. - Publication Year :
- 2018
-
Abstract
- Carbapenemase-producing organisms are pandemic and a significant threat to public health. We investigated the clonal relatedness of colistin-resistant Klebsiella pneumoniae strains producing KPC-type carbapenemase (KPC-KP) causing subsequent infections or colonization. Moreover, we aimed to gain insight into the ability of biofilm production in K. pneumoniae strains producing carbapenemase. Twenty-two consecutive KPC-KP and one KPC-negative strain was identified from an adult intensive care unit in Brazil. Seventy-five percent of isolates that harbored the bla <subscript>KPC</subscript> gene exhibited genetic relatedness by pulsed-field gel electrophoresis, and none presented the plasmid-mediated mcr-1 and bla <subscript>NDM</subscript> genes. This study showed that the majority of repeated KPC infections in adults were caused by a clone that caused the previous infections/colonizations even after a long period of time and illustrates the capacity of multiple clones producing biofilms to coexist in the same patient at the same time, becoming a reservoir of KPC-KP in the hospital environment.
- Subjects :
- Adult
Bacterial Adhesion
Bacterial Proteins biosynthesis
Biofilms
Brazil
Colony Count, Microbial
Cross Infection microbiology
Drug Resistance, Multiple, Bacterial genetics
Humans
Klebsiella Infections mortality
Microbial Sensitivity Tests
beta-Lactamases biosynthesis
Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Colistin pharmacology
Drug Resistance, Bacterial drug effects
Klebsiella Infections microbiology
Klebsiella pneumoniae genetics
beta-Lactamases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1931-8448
- Volume :
- 24
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Microbial drug resistance (Larchmont, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 29792779
- Full Text :
- https://doi.org/10.1089/mdr.2018.0043