Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques.

Authors :: Kovtunov KV
Pokochueva EV
Salnikov OG
Cousin SF
Kurzbach D
Vuichoud B
Jannin S
Chekmenev EY
Goodson BM
Barskiy DA
Koptyug IV
Source :: Chemistry, an Asian journal [Chem Asian J] 2018 May 23. Date of Electronic Publication: 2018 May 23.
Publication Year :: 2018
Publisher :: Ahead of Print
Abstract: The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules. Such approaches can overcome the main sensitivity challenges facing modern NMR/magnetic resonance imaging (MRI) techniques, whilst hyperpolarized fluids can also be used in a variety of applications in material science and biomedicine. This Focus Review considers the fundamentals of the preparation of hyperpolarized liquids and gases by using dissolution dynamic nuclear polarization (d-DNP) and parahydrogen-based techniques, such as signal amplification by reversible exchange (SABRE) and parahydrogen-induced polarization (PHIP), in both heterogeneous and homogeneous processes. The various new aspects in the formation and utilization of hyperpolarized fluids, along with the possibility of observing NMR signal enhancement, are described.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)