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Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: A pilotstudy.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2018 Oct; Vol. 20 (10), pp. 2330-2338. Date of Electronic Publication: 2018 Jun 10. - Publication Year :
- 2018
-
Abstract
- Aims: Peripheral infusion of glucagon-like peptide-1 (GLP-1) can affect brain activity in areas involved in the regulation of appetite, including hypothalamic and reward-related brain regions. In contrast, the physiological role of endogenous GLP-1 in the central regulation of appetite has hardly been investigated.<br />Materials and Methods: This was a randomized, cross-over trial that involved 12 healthy volunteers who received an intragastric (ig) glucose (gluc) load, with or without intravenous (iv) exendin9-39 (ex9-39; specific GLP-1 receptor antagonist). Functional magnetic resonance imaging was used to investigate the effect of endogenous GLP-1 on resting state functional connectivity (rsFC) between homeostatic and reward-related brain regions. Visual analogue scales were used to rate appetite-related sensations. Blood samples were collected for GI hormone measurements.<br />Results: Administration of iv-ex9-39/ig-gluc induced a significantly higher rsFC, relative to ig-gluc administration, between the hypothalamus and the left lateral orbitofrontal cortex (OFC) as well as the left amygdala (P ≤ .001, respectively). Administration of iv-ex9-39/ig-gluc induced a significantly higher rsFC, relative to ig-gluc administration, between the right nucleus accumbens and the right lateral OFC (P < .001). Administration of iv-ex9-39/ig-gluc induced a significantly lower rsFC, relative to ig-gluc administration, between the midbrain and the right caudate nucleus (P = .001). Administration of ig-gluc significantly decreased prospective food consumption and increased sensations of fullness compared to pre-infusion baseline (P = .028 and P = .019, respectively); these effects were not present in the iv-ex9-39/ig-gluc condition.<br />Conclusions: This pilot trial provides preliminary experimental evidence that glucose-induced endogenous GLP-1 affects central regulation of appetite by modulating rsFC in homeostatic and reward-related brain regions in healthy lean male participants in a GLP-1 receptor-mediated fashion.<br /> (© 2018 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Appetite drug effects
Brain drug effects
Cross-Over Studies
Glucagon-Like Peptide 1 blood
Glucose administration & dosage
Glucose pharmacology
Healthy Volunteers
Homeostasis drug effects
Humans
Male
Nerve Net drug effects
Pilot Projects
Postprandial Period drug effects
Young Adult
Appetite Regulation drug effects
Brain physiology
Glucagon-Like Peptide 1 physiology
Peptide Fragments pharmacology
Reward
Thinness blood
Thinness metabolism
Thinness physiopathology
Thinness psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 20
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 29790260
- Full Text :
- https://doi.org/10.1111/dom.13369