In Vitro and In Vivo Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis.

Authors :: Shoen C
DeStefano M
Hafkin B
Cynamon M
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Jul 27; Vol. 62 (8). Date of Electronic Publication: 2018 Jul 27 (Print Publication: 2018).
Publication Year :: 2018
Abstract: The in vitro activity of contezolid (MRX-I) against clinical isolates of Mycobacterium tuberculosis was evaluated using a microtiter broth dilution assay. MRX-I was as effective as linezolid (LZD) in vitro MRX-I and LZD were subsequently studied in BALB/c mice infected intranasally with M. tuberculosis Erdman. MRX-I and LZD at 100 mg/kg significantly reduced the bacterial load in lungs compared to the untreated early and late controls.<br /> (Copyright © 2018 American Society for Microbiology.)

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