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Live-Cell Imaging of Early Steps of Single HIV-1 Infection.

Authors :
Francis AC
Melikyan GB
Source :
Viruses [Viruses] 2018 May 19; Vol. 10 (5). Date of Electronic Publication: 2018 May 19.
Publication Year :
2018

Abstract

Live-cell imaging of single HIV-1 entry offers a unique opportunity to delineate the spatio-temporal regulation of infection. Novel virus labeling and imaging approaches enable the visualization of key steps of HIV-1 entry leading to nuclear import, integration into the host genome, and viral protein expression. Here, we discuss single virus imaging strategies, focusing on live-cell imaging of single virus fusion and productive uncoating that culminates in HIV-1 infection.

Subjects

Subjects :
HIV Infections virology
HIV-1 physiology
Humans
Models, Biological
Single-Cell Analysis
Viral Proteins chemistry
Viral Proteins metabolism
Virus Internalization
Virus Uncoating
Cell Nucleus metabolism
HIV Infections pathology
HIV-1 metabolism
Optical Imaging

Details

Language :
English
ISSN :
1999-4915
Volume :
10
Issue :
5
Database :
MEDLINE
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
29783762
Full Text :
https://doi.org/10.3390/v10050275
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