Modular Nanotransporter with P21 Fragment Inhibits DNA Repair after Bleomycin Treatment.

Authors :: Kamaletdinova TR
Rosenkranz AA
Ulasov AV
Khramtsov YV
Tsvetkova AD
Georgiev GP
Sobolev AS
Source :: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2018 Mar; Vol. 479 (1), pp. 95-97. Date of Electronic Publication: 2018 May 19.
Publication Year :: 2018
Abstract: Modular nanotransporter (MNT) with C-terminal fragment of the p21 protein was synthesized and characterized, and its effect on DNA lesions was studied. This p21 fragment in MNT can significantly inhibit DNA repair in A431 human carcinoma cells after bleomycin treatment.

Subjects :: Cell Line, Tumor
Humans
Bleomycin pharmacology
Cyclin-Dependent Kinase Inhibitor p21 chemistry
DNA Repair drug effects
Drug Carriers chemistry
Nanostructures chemistry
Peptide Fragments chemistry

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