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Effectiveness of HPV vaccination against high grade cervical lesions in Japan.
- Source :
-
Vaccine [Vaccine] 2018 Dec 18; Vol. 36 (52), pp. 7913-7915. Date of Electronic Publication: 2018 May 21. - Publication Year :
- 2018
-
Abstract
- The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69% lower risk of HSIL+ as compared to the unvaccinated women; the crude relative risk estimate was 0.31 (95% CI: 0.11-0.83; p-value = 0.013) by normal approximation and 0.31 (95% CI: 0.08-0.80; p-value = 0.009) by the exact Poisson regression. The effect of age was not significant (chisq = 7.7 (df = 9), p-value = 0.569) and the estimate of relative risk remained essentially intact after adjustment for age. This study brings scientific evidence on the effectiveness of HPV vaccine on development of cervical high grade lesions.<br /> (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Adult
Cohort Studies
Female
Humans
Japan
Mass Screening
Regression Analysis
Uterine Cervical Neoplasms diagnosis
Vaccine Potency
Young Adult
Uterine Cervical Dysplasia diagnosis
Papillomavirus Infections prevention & control
Papillomavirus Vaccines therapeutic use
Uterine Cervical Neoplasms prevention & control
Vaccination statistics & numerical data
Uterine Cervical Dysplasia prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 36
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 29778520
- Full Text :
- https://doi.org/10.1016/j.vaccine.2018.05.048