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[The significance of lymphocyte to monocyte ratio in peripheral blood of patients with benign and malignant laryngeal lesions].
- Source :
-
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2017 Jun 05; Vol. 31 (11), pp. 835-838. - Publication Year :
- 2017
-
Abstract
- Objective: The aim of this study is to investigate the value of preoperative peripheral blood lymphocyte to monocyte ratio (LMR) in differentiating laryngeal squamous cell carcinoma (LSCC), laryngeal precancerous lesions (LPL) and laryngeal benign lesions (LBL). Method: Four hundred and five cases of laryngeal lesions diagnosed by pathology (154 cases of LSCC, 83 cases of LPL and 168 cases of LBL) were collected. LSCC group was further divided into T1 group, T2 group and T3-4 group based on T stage. The levels of neutrophils, lymphocytes, monocytes, hemoglobin, platelet and other blood indexes were measured, as well as compared the LMR, neutrophil to lymphocyte ratio (NLR) and other parameters in each group. Result: The LMR and NLR in LBL, LPL and LSCC groups was 4.88±1.65 and 4.61±1.59, 3.92±1.77 and 2.11±0.79, 2.08±0.77 and 2.63±1.69, respectively. The LMR in the LSCC group was significantly lower than those in the LBL and LPL group ( P <0.01), whereas the NLR was significantly higher than those in LBL and LPL group ( P <0.05). Either LMR or NLR between the LBL and LPL group was not statistically different ( P >0.05). The LMR of patients with local advanced (T3-4) stage in the LSCC group was lower than that in the early or medium stage (T1-2), while the NLR was higher and the difference was statistically significant ( P <0.05). There was no significant difference in platelet, white blood cell and neutrophil count between LBL, LPL and LSCC ( P >0.05). Conclusion: We, for the first time, compared LMR in different laryngeal lesions and found that LMR and NLR as a systemic inflammatory index have a certain reference value for to differentiate LSCC from LPL and LBL.<br />Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.<br /> (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)
- Subjects :
- Carcinoma, Squamous Cell diagnosis
Humans
Laryngeal Diseases blood
Laryngeal Diseases diagnosis
Laryngeal Neoplasms diagnosis
Lymphocyte Count
Prognosis
Retrospective Studies
Carcinoma, Squamous Cell blood
Laryngeal Neoplasms blood
Lymphocytes cytology
Monocytes cytology
Neutrophils cytology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 2096-7993
- Volume :
- 31
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29774997
- Full Text :
- https://doi.org/10.13201/j.issn.1001-1781.2017.11.005