New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum .

Authors :: Tani K
Kamada T
Phan CS
Vairappan CS
Source :: Natural product research [Nat Prod Res] 2019 Dec; Vol. 33 (23), pp. 3343-3349. Date of Electronic Publication: 2018 May 17.
Publication Year :: 2019
Abstract: Three new cembrane diterpenes, nephthecrassocolides A-B ( 1 - 2 ) and 6-acetoxy nephthenol acetate ( 3 ) along with three known compounds, 6-acetoxy-7,8-epoxy nephthenol acetate ( 4 ), epoxy nephthenol acetate ( 5 ) and nephthenol ( 6 ) were isolated from one population of Nephthea sp. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1 - 6 were evaluated.

Subjects :: Animals
Drug Evaluation, Preclinical
Lagenidium drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Structure-Activity Relationship
Anthozoa chemistry
Antifungal Agents chemistry
Antifungal Agents pharmacology
Diterpenes chemistry
Diterpenes pharmacology

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