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A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2018 May 25; Vol. 152, pp. 570-589. Date of Electronic Publication: 2018 May 07. - Publication Year :
- 2018
-
Abstract
- Alzheimer's disease (AD), the most common form of dementia, is a multifactorial neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta-secretase, monoamine oxidase and inhibition of amyloid-β aggregation as well as oxidative stress and metal chelation play an important role in the pathogenesis of AD. Chroman-4-one scaffold with benzo-γ-pyrone network is a privileged structure in organic synthesis and drug design. A large number of research has been carried out on modified naturally occurring chromanone scaffolds and/or synthesized new analogues, to obtain effective drugs for AD management. The present review summarizes aspects related to the multi-target-directed ligands (MTDLs) strategy in enzyme targets modulation performed with natural and synthesized chroman-4-one-based structures to look at their potential in the management of multifactorial Alzheimer's disease.<br /> (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Alzheimer Disease metabolism
Amyloid Precursor Protein Secretases metabolism
Animals
Aspartic Acid Endopeptidases metabolism
Cholinesterase Inhibitors chemistry
Cholinesterases metabolism
Flavonoids chemistry
Humans
Ligands
Monoamine Oxidase metabolism
Monoamine Oxidase Inhibitors chemistry
Alzheimer Disease drug therapy
Amyloid Precursor Protein Secretases antagonists & inhibitors
Aspartic Acid Endopeptidases antagonists & inhibitors
Cholinesterase Inhibitors pharmacology
Flavonoids pharmacology
Monoamine Oxidase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 152
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29763806
- Full Text :
- https://doi.org/10.1016/j.ejmech.2018.05.004