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Visual Rating and Computer-Assisted Analysis of FDG PET in the Prediction of Conversion to Alzheimer's Disease in Mild Cognitive Impairment.
- Source :
-
Molecular diagnosis & therapy [Mol Diagn Ther] 2018 Aug; Vol. 22 (4), pp. 475-483. - Publication Year :
- 2018
-
Abstract
- Background: Fluorodeoxyglucose (FDG) positron emission tomography (PET) is useful to predict Alzheimer's disease (AD) conversion in patients with mild cognitive impairment (MCI). However, few studies have examined the extent to which FDG PET alone can predict AD conversion and compared the efficacy between visual and computer-assisted analysis directly.<br />Objective: The current study aimed to evaluate the value of FDG PET in predicting the conversion to AD in patients with MCI and to compare the predictive values of visual reading and computer-assisted analysis.<br />Methods and Materials: A total of 54 patients with MCI were evaluated with FDG PET and followed-up for 2 years with final diagnostic evaluation. FDG PET images were evaluated by (1) traditional visual rating, (2) composite score of visual rating of the brain cortices, and (3) composite score of computer-assisted analysis. Receiver operating characteristics (ROC) curves were compared to analyze predictive values.<br />Results: Nineteen patients (35.2%) converted to AD from MCI. The area under the curve (AUC) of the ROC curve of the traditional visual rating, composite score of visual rating, and computer-assisted analysis were 0.67, 0.76, and 0.79, respectively. ROC curves of the composite scores of the visual rating and computer-assisted analysis were comparable (Z = 0.463, p = 0.643).<br />Conclusions: Visual rating and computer-assisted analysis of FDG PET scans were analogously accurate in predicting AD conversion in patients with MCI. Therefore, FDG PET may be a useful tool for screening AD conversion in patients with MCI, when using composite score, regardless of the method of interpretation.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease physiopathology
Area Under Curve
Cognitive Dysfunction psychology
Diagnosis, Differential
Female
Humans
Image Interpretation, Computer-Assisted
Male
Middle Aged
Neuropsychological Tests
ROC Curve
Alzheimer Disease diagnosis
Cognitive Dysfunction diagnosis
Fluorodeoxyglucose F18
Image Processing, Computer-Assisted
Positron-Emission Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 1179-2000
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular diagnosis & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 29761365
- Full Text :
- https://doi.org/10.1007/s40291-018-0334-z