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The asymmetry of neural symptoms in Wilson's disease patients detecting by diffusion tensor imaging, resting-state functional MRI, and susceptibility-weighted imaging.
- Source :
-
Brain and behavior [Brain Behav] 2018 Apr 14; Vol. 8 (5), pp. e00930. Date of Electronic Publication: 2018 Apr 14 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Objective: To investigate the cause of the motor asymmetry in Wilson's disease (WD) patients using functional MRI.<br />Methods: Fifty patients with WD and 20 age-matched healthy controls were enrolled. Neurological symptoms were scored using the modified Young Scale. All study subjects underwent diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI), and resting-state functional MRI (rs-fMRI) of the brain. Six regions of interest (ROI) were chosen. Fiber volumes between ROIs on DTI, corrected phase (CP) values on SWI, amplitude of low-frequency fluctuation (ALFF), and regional homogeneity (REHO) values on rs-fMRI were determined. Asymmetry index (right or left value/left or right value) was evaluated.<br />Results: Asymmetry of rigidity, tremor, choreic movement, and gait abnormality (asymmetry index = 1.33, 1.39, 1.36, 1.40), fiber tracts between the GP and substantia nigra (SN), GP and PU, SN and thalamus (TH), SN and cerebellum, head of the caudate nucleus (CA) and SN, PU and CA, CA and TH, TH and cerebellum (asymmetry index = 1.233, 1.260, 1.269, 1.437, 1.503, 1.138, 1.145, 1.279), CP values in the TH, SN (asymmetry index = 1.327, 1.166), ALFF values, and REHO values of the TH (asymmetry index = 1.192, 1.233) were found. Positive correlation between asymmetry index of rigidity and fiber volumes between the GP and SN, SN and TH ( r  = .221, .133, p  = .043, .036), and tremor and fiber volumes between the CA and TH ( r  = .045, p  = .040) was found.<br />Conclusions: The neurological symptoms of patients with WD were asymmetry. The asymmetry of fiber projections may be the main cause of motor asymmetry in patients with WD.
- Subjects :
- Adolescent
Adult
Brain pathology
Case-Control Studies
Caudate Nucleus diagnostic imaging
Caudate Nucleus pathology
Cerebellum diagnostic imaging
Cerebellum pathology
Chorea etiology
Chorea physiopathology
Diffusion Tensor Imaging
Female
Functional Laterality
Functional Neuroimaging
Gait Disorders, Neurologic etiology
Gait Disorders, Neurologic physiopathology
Globus Pallidus diagnostic imaging
Globus Pallidus pathology
Hepatolenticular Degeneration complications
Hepatolenticular Degeneration pathology
Hepatolenticular Degeneration physiopathology
Humans
Magnetic Resonance Imaging
Male
Muscle Rigidity etiology
Muscle Rigidity physiopathology
Organ Size
Putamen diagnostic imaging
Putamen pathology
Substantia Nigra diagnostic imaging
Substantia Nigra pathology
Thalamus diagnostic imaging
Thalamus pathology
Tremor etiology
Tremor physiopathology
Young Adult
Brain diagnostic imaging
Hepatolenticular Degeneration diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2162-3279
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Brain and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 29761003
- Full Text :
- https://doi.org/10.1002/brb3.930