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The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials.
- Source :
-
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2018; Vol. 14 (9), pp. 2107-2113. Date of Electronic Publication: 2018 Jun 18. - Publication Year :
- 2018
-
Abstract
- The devastating Ebola virus (EBOV) epidemic in West Africa in 2013-2016 accelerated the progress of several vaccines and antivirals through clinical trials, including the replication-competent vesicular stomatitis virus-based vaccine expressing the EBOV glycoprotein (VSV-EBOV). Extensive preclinical testing in animal models demonstrated the prophylactic and post-exposure efficacy of this vaccine, identified the mechanism of protection, and suggested it was safe for human use. Based on these data, VSV-EBOV was extensively tested in phase 1-3 clinical trials in North America, Europe and Africa. Although some side effects of vaccination were observed, these clinical trials showed that the VSV-EBOV was safe and immunogenic in humans. Moreover, the data supported the use of VSV-EBOV as an emergency vaccine in individuals at risk for Ebola virus disease. In this review, we summarize the results of the extensive preclinical and clinical testing of the VSV-EBOV vaccine.
- Subjects :
- Animals
Clinical Trials as Topic
Drug Evaluation, Preclinical
Drug-Related Side Effects and Adverse Reactions epidemiology
Drug-Related Side Effects and Adverse Reactions pathology
Ebola Vaccines administration & dosage
Ebola Vaccines genetics
Humans
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated genetics
Vaccines, Attenuated immunology
Vaccines, Attenuated isolation & purification
Vaccines, Synthetic administration & dosage
Vaccines, Synthetic genetics
Vaccines, Synthetic immunology
Vaccines, Synthetic isolation & purification
Drug Carriers
Ebola Vaccines immunology
Ebola Vaccines isolation & purification
Hemorrhagic Fever, Ebola prevention & control
Vesiculovirus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2164-554X
- Volume :
- 14
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Human vaccines & immunotherapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 29757706
- Full Text :
- https://doi.org/10.1080/21645515.2018.1473698