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Molecular Determinants of Target Cell Recognition by Human γδ T Cells.
- Source :
-
Frontiers in immunology [Front Immunol] 2018 Apr 27; Vol. 9, pp. 929. Date of Electronic Publication: 2018 Apr 27 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a mechanistic standpoint, numerous studies have unveiled a remarkable flexibility of γδ T cells in employing their T cell receptor and/or NK cell receptors for target cell recognition, even if the relevant ligands often remain uncertain. Here, we review the accumulated knowledge on the diverse mechanisms of target cell recognition by γδ T cells, focusing on human γδ T cells, to provide an integrated perspective of their therapeutic potential in cancer and infectious diseases.
- Subjects :
- Animals
Antigens, Neoplasm immunology
Antigens, Neoplasm metabolism
Cell Communication
Communicable Diseases etiology
Communicable Diseases metabolism
Epitopes, T-Lymphocyte immunology
Humans
Ligands
Neoplasms genetics
Neoplasms immunology
Neoplasms metabolism
Protein Binding immunology
Receptors, Antigen, T-Cell, gamma-delta metabolism
T-Cell Antigen Receptor Specificity genetics
T-Cell Antigen Receptor Specificity immunology
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29755480
- Full Text :
- https://doi.org/10.3389/fimmu.2018.00929