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Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease.
- Source :
-
Seminars in nephrology [Semin Nephrol] 2018 May; Vol. 38 (3), pp. 233-250. - Publication Year :
- 2018
-
Abstract
- In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth factor-23 and phosphate levels. The resulting CKD-associated disorder of mineral and bone metabolism is associated with various other metabolic dysregulations such as acidosis, malnutrition, inflammation, and accumulation of uremic toxins. It favors the occurrence of vascular calcification, which results from an imbalance between numerous inhibitors and promoters of soft-tissue mineralization. This review provides an overview of the most recent state of knowledge concerning the mechanisms that lead to the development of vascular calcification in the CKD setting. It further proposes directions for potential new therapeutic targets.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents therapeutic use
Calcimimetic Agents therapeutic use
Calcium metabolism
Chelating Agents therapeutic use
Fibroblast Growth Factor-23
Fibroblast Growth Factors metabolism
Glucuronidase metabolism
Glycation End Products, Advanced metabolism
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Indican metabolism
Inflammation complications
Inflammation drug therapy
Klotho Proteins
Magnesium therapeutic use
Mesenchymal Stem Cells metabolism
Mesenchymal Stem Cells pathology
Phosphates metabolism
Renal Insufficiency, Chronic complications
Tunica Intima pathology
Tunica Media pathology
Vascular Calcification pathology
Vascular Calcification prevention & control
Vitamin K 2 therapeutic use
Zinc Finger Protein GLI1 metabolism
Cardiovascular Diseases metabolism
Cardiovascular Diseases prevention & control
Renal Insufficiency, Chronic metabolism
Vascular Calcification drug therapy
Vascular Calcification metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1558-4488
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Seminars in nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 29753400
- Full Text :
- https://doi.org/10.1016/j.semnephrol.2018.02.004