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The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2018 Jul; Vol. 150 (1), pp. 151-157. Date of Electronic Publication: 2018 May 10. - Publication Year :
- 2018
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Abstract
- Objective: To investigate the association of cancer stem cell biomarker aldehyde dehydrogenase-1 (ALDH1) with ovarian cancer patients' prognosis and clinico-pathological characteristics.<br />Methods: The electronic searches were performed in January 2018 through the databases PubMed, MEDLINE and Scopus by searching the terms: "ovarian cancer" AND "immunohistochemistry" AND ["aldehyde dehydrogenase-1" OR "ALDH1" OR "cancer stem cell"]. Studies evaluating the impact of ALDH1 expression on ovarian cancer survival and clinico-pathological variables were selected.<br />Results: 233 studies were retrieved. Thirteen studies including 1885 patients met all selection criteria. ALDH1-high expression was found to be significantly associated with poor 5-year OS (OR = 3.46; 95% CI: 1.61-7.42; P = 0.001, random effects model) and 5-year PFS (OR = 2.14; 95% CI: 1.11-4.13; P = 0.02, random effects model) in ovarian cancer patients. No correlation between ALDH1 expression and tumor histology (OR = 0.60; 95% CI: 0.36-1.02; P = 0.06, random effects model), FIGO Stage (OR = 0.65; 95% CI: 0.33-1.30; P = 0.22, random effects model), tumor grading (OR = 0.76; 95% CI: 0.40-1.45; P = 0.41, random effects model) lymph nodal status (OR = 2.05; 95% CI: 0.81-5.18; P = 0.13, random effects model) or patients' age at diagnosis (OR = 0.83; 95% CI: 0.54-1.29; P = 0.41, fixed effects model) was identified.<br />Conclusions: Basing on the available evidence, this meta-analysis showed that high levels of ALDH1 expression correlate with worse OS and PFS in ovarian cancer patients.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Aldehyde Dehydrogenase 1 Family
Female
Humans
Isoenzymes metabolism
Ovarian Neoplasms blood
Ovarian Neoplasms mortality
Ovarian Neoplasms pathology
Prognosis
Retinal Dehydrogenase metabolism
Survival Analysis
Isoenzymes biosynthesis
Ovarian Neoplasms enzymology
Retinal Dehydrogenase biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 150
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 29753392
- Full Text :
- https://doi.org/10.1016/j.ygyno.2018.05.006